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Expression of genes related to muscle plasticity after strength and power training regimens
Author(s) -
Lamas L.,
Aoki M. S.,
Ugrinowitsch C.,
Campos G. E. R.,
Regazzini M.,
Moriscot A. S.,
Tricoli V.
Publication year - 2010
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2009.00905.x
Subject(s) - muscle hypertrophy , calcineurin , pi3k/akt/mtor pathway , strength training , gene expression , medicine , endocrinology , biology , andrology , gene , physiology , signal transduction , microbiology and biotechnology , biochemistry , transplantation
The purpose of our study was to compare the effects of 8‐week progressive strength and power training regimens on strength gains and muscle plasticity [muscle fiber hypertrophy and phenotype shift, mammalian target of rapamycin (mTOR), regulatory‐associated protein of mTOR (RAPTOR), rapamycin‐insensitive companion of m‐TOR (RICTOR), calcineurin and calcipressin gene expression]. Twenty‐nine physically active subjects were divided into three groups: strength training (ST), power training (PT) and control (C). Squat 1 RM and muscle biopsies were obtained before and after the training period. Strength increased similarly for both ST and PT groups ( P <0.001). Fiber types I, IIa and IIb presented hypertrophy main time effect ( P <0.05). Only type IIb percentage decreased from pre‐ to post‐test (main time effect, P <0.05). mTOR and RICTOR mRNA expression increased similarly from pre‐ to post‐test ( P <0.01). RAPTOR increased after training for both groups ( P <0.0001), but to a greater extent in the ST ( P <0.001) than in the PT group. 4EBP‐1 decreased after training when the ST and PT groups were pooled ( P <0.05). Calcineurin levels did not change after training, while calcipressin increased similarly from pre‐ to post‐test ( P <0.01). In conclusion, our data indicate that these training regimens produce similar performance improvements; however, there was a trend toward greater hypertrophy‐related gene expression and muscle fiber hypertrophy in the ST group.