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Interleukin‐6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen
Author(s) -
Gusba J. E.,
Wilson R. J.,
Robinson D. L.,
Graham T. E.
Publication year - 2008
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2006.00635.x
Subject(s) - glycogen , medicine , endocrinology , carbohydrate , biology , chemistry
Increases in circulating interleukin‐6 (IL‐6) during exhaustive exercise have been suggested to be related to declining muscle glycogen. We addressed two hypotheses: (a) exhaustive exercise on two occasions will result in similar decreases in glycogen and increases in circulating IL‐6 and its muscle mRNA; (b) increasing the rate of glycogen restoration via high‐carbohydrate feeding in recovery will be associated with more rapid declines in muscle mRNA and circulating IL‐6. Ten male subjects (22.6±0.8 year) cycled to exhaustion (65% VO 2 max ) on two occasions (117.8±2.9 min). Carbohydrate (1 g/kg bw) or water was ingested at exhaustion, 60, 120, 180, and 240 min post‐exercise. Muscle biopsies were taken at rest, exhaustion, 30, 60, 120 and 300 min of recovery. Exercise resulted in a 14.5‐fold increase ( P <0.05) in IL‐6 mRNA, 14.4‐fold increase ( P <0.05) in circulating IL‐6, and a 80% decrease ( P <0.05) in muscle glycogen from rest. The decline in glycogen was not correlated with the increase in IL‐6 or IL‐6 mRNA. During recovery, circulating IL‐6 and its muscle mRNA decreased similarly in both trials; however, glycogen increased 150% ( P <0.05) and 40% in the carbohydrate and water trials, respectively. Therefore, the declining IL‐6 mRNA and IL‐6 plasma concentrations during recovery were not related to carbohydrate availability or changes in glycogen.