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Effect of nedocromil sodium on exercise‐induced bronchoconstriction exacerbated by inhalation of cold air
Author(s) -
Oseid S.,
Mellbye E.,
Hem E.
Publication year - 1995
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.1995.tb00018.x
Subject(s) - nedocromil sodium , bronchoconstriction , methacholine , medicine , placebo , inhalation , nedocromil , crossover study , anesthesia , asthma , exercise induced asthma , common cold , airway , respiratory disease , lung , immunology , alternative medicine , pathology
This double‐blind placebo‐crossover study examined the effect of nedocromil sodium, 4 mg aerosol 30 min before challenge, on exercise‐induced bronchoconstriction (EIB) in cold air conditions. Twenty‐one asthmatic patients (15–28 years), with methacholine PC 20 ≤8 mg/ml in the absence of significant allergen exposure, were randomized to active and placebo therapy on separate study days. Pulmonary function, measured up to 20 min after exercise, showed significantly less deterioration with nedocromil sodium, which effectively halved the maximum percentage decline in forced expiratory volume in the first second. EIB was increased by cold air, whereas an ancillary study in 15 healthy volunteers (18–19 years) showed no such effects. We conclude that prior inhalation of nedocromil sodium diminished cold air‐exacerbated EIB in young adult asthmatic patients.