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Dual effects of melatonin on oxidative stress after surgical brain injury in rats
Author(s) -
Lee Steve,
Jadhav Vikram,
Ayer Robert E.,
Rojas Hugo,
Hyong Amy,
Lekic Tim,
Tang Jiping,
Zhang John H.
Publication year - 2009
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.2008.00607.x
Subject(s) - melatonin , oxidative stress , lipid peroxidation , neuroprotection , medicine , brain edema , edema , anesthesia , pharmacology , endocrinology
The purpose of this study was to evaluate the effect of melatonin on oxidative stress occurring in the brain after routine lobectomy neurosurgery procedures. Different concentrations of melatonin (5, 15 and 150 mg/kg) were administered 1 hr before lobectomy in a rodent surgical brain injury (SBI) model. Neurological outcomes were assessed 24 hr before the killing of the rodents, for evaluation of brain water content (brain edema) and lipid peroxidation (oxidative stress). The results showed that lower doses (5 and 15 mg/kg) failed to reduce brain edema, but the 15 mg/kg dose did lower oxidative stress and improved several neurological parameters. High concentration of melatonin (150 mg/kg) significantly increased brain edema and elevated oxidative stress when compared with the vehicle‐treated group. Furthermore, high‐dose melatonin also worsened neurological outcomes compared with other groups. The study suggests that melatonin has dual effects: low‐dose melatonin may provide neuroprotective effects against SBI but a high dose may aggravate some parameters after SBI.