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Contrast‐induced nephropathy: preventive and protective effects of melatonin
Author(s) -
Gazi Sabri,
Altun Armagan,
Erdogan Okan
Publication year - 2006
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.2006.00336.x
Subject(s) - melatonin , medicine , contrast induced nephropathy , endocrinology , nephropathy , creatinine , fractional excretion of sodium , oxidative stress , renal function , excretion , chemistry , diabetes mellitus
Infusion of contrast agents increases osmotic load, viscosity, hypoxemia of the renal medulla and renal free radical production through post‐ischemic oxidative stress. The present experimental study sought to determine whether melatonin, because of its anti‐oxidant properties might have a preventive and protective role against the development of contrast‐induced nephropathy (CIN). Twenty‐four adult male rats were divided into four experimental groups: healthy control rats (CR), rats with CIN (CINR), rats with CIN pretreated with melatonin (CINR1M), and rats with CIN pre‐ and post‐treated with melatonin (CINR2M). In CINR, both serum creatinine (Cr) level and fractional excretion of sodium (FE‐Na) significantly increased, whereas Cr clearance decreased at post‐CIN compared with pre‐CIN period. Rats in CINR1M did not show any improvement in renal function. Cr clearance decreased, whereas both serum Cr level and FE‐Na increased in rats pretreated with melatonin. In contrast, significant improvements were observed in CINR2M. Serum Cr and Cr clearance did not change, whereas FE‐Na significantly reduced in rats pre‐ and post‐treated with melatonin. In conclusion, the present experimental study clearly demonstrated the preventive and protective role of melatonin against the development of CIN.