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The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans
Author(s) -
Matsumoto Miki,
Sack Robert L.,
Blood Mary L.,
Lewy Alfred J.
Publication year - 1997
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1997.tb00301.x
Subject(s) - melatonin , endogeny , bedtime , endocrinology , medicine , pineal gland , placebo , circadian rhythm , biology , alternative medicine , pathology
Matsumoto M, Sack RL, Blood ML, Lewy AJ. The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans. J. Pineal Res. 1997; 22:42–44. © Munksgaard, Copenhagen Abstract A physiological dose of melatonin (0.5 mg) or placebo was given at bedtime to night shift workers (n=21) for seven days, and endogenous melatonin profiles were measured on the eighth day. The amplitude of endogenous melatonin secretion was unchanged by treatment. Also, a melatonin treatment trial using a 50 mg daily bedtime dose for 37 days to a blind subject resulted in no change in the endogenous melatonin profile. We conclude that circulating melatonin can shift the phase, but does not alter the amplitude, of pineal melatonin secretion.