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Direct influence of melatonin on steroid, Nona peptide hormones, and cyclic nucleotide secretion by granulosa cells isolated from porcine ovaries
Author(s) -
Sirotkin Alexander V.
Publication year - 1994
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1994.tb00121.x
Subject(s) - melatonin , medicine , endocrinology , vasopressin , oxytocin , secretion , hormone , stimulation , peptide hormone , biology , cyclic nucleotide , arginine , chemistry , nucleotide , amino acid , biochemistry , gene
Sirotkin AV. Direct influence of melatonin on steroid, nonapeptide hormones, and cyclic nucleotide secretion by granulosa cells from porcine ovaries. J. Pineal Res. 1994; 17: 112–117. Abstract The release of progesterone, estradiol‐173, oxytocin, arginine‐vasopressin, cAMP, and cGMP by cultured granulosa cells isolated from porcine ovaries without and in the presence of melatonin (0. 001, 0. 01, 0. 1, 1, 10, and 100 ng/ml medium) was analyzed. It was found that melatonin is able to inhibit progesterone and stimulate estuarial secretion. Melatonin treatments significantly inhibited oxytocin release. Some inhibition of vasopressin and cAMP and significant stimulation of cGMP also resulted from melatonin treatment. The present observations suggest a direct effect of melatonin on the steroid, nonapeptide hormone, and cyclic nucleotide release from porcine ovarian cells.