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Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide
Author(s) -
Guerrero Juan M.,
Reiter Russel J.,
Poeggeler Burkhard,
Chen LiDun,
Tan DunXian
Publication year - 1994
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1994.tb00104.x
Subject(s) - sodium nitroprusside , vasoactive intestinal peptide , nitric oxide , cyclic gmp , medicine , endocrinology , pineal gland , activator (genetics) , arginine , chemistry , cyclic nucleotide , melatonin , forskolin , biology , nucleotide , biochemistry , neuropeptide , stimulation , receptor , amino acid , gene
Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. Abstract The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.