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Effect of pinealectomy upon the nonspecific immune response of the ring‐dove (Streptopelia risoria)
Author(s) -
Rodriguez Ana B.,
Lea Robert W.
Publication year - 1994
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1994.tb00096.x
Subject(s) - streptopelia , pinealectomy , medicine , endocrinology , immune system , corticosterone , dove , ingestion , chemistry , phagocytosis , hormone , biology , melatonin , pineal gland , immunology , political science , law
Rodriguez AB, Lea RW. Effect of pinealectomy upon the nonspecific immune response of the ring‐dove ( Streptopelia risoria ). J. Pineal Res. 1994; 16: 159–166. Abstract The different stages of the phagocytic process by granulocytes of pinealectomized or sham‐pinealectomized ring doves ( Streptopelia risoria) as well as hematological parameters (total white blood cells, smear, and total protein) and serum hormone levels (triiodothyronine (T 3 ), thyroxine (T 4 ), and corticosterone) were studied. A number of immunological parameters of the phagocytosis process, including adherence capacity, mobility rate, the phagocytosis capacity for inert particles and the digestion capacity of ingested material, were studied. Adult male ring doves were injected intravenously with either 0. 1 ml of normal sheep serum (NSS) or saline (SS). Blood samples were collected before injection, and 1 hr, 3 hr, 24 hr, and 4 days afterwards. The results indicate that pinealectomy produces a significant increase in the number of total white blood cells and total protein concentration in plasma in addition to altering different stages of the phagocytic process. During the immunization study, a decrease in the percentage of leukocytes and lymphocytes and an increase in the percentage of heterophils accompanied by an increase in the concentration of serum corticosterone were observed 3 hr following treatment. For the immunological parameters, adherence capacity and latex bead ingestion were increased 3 hr after NSS injection and the NBT reduction test 3 and 24 hr after NSS treatment. In addition, the administration of NSS produced a significant increase in serum T 3 and T 4 concentrations 4 days following injection. These results show that pinealectomy has a marked effect on both the number and function of immune cells.