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Differential regulation of melatonin receptors by short‐ versus long‐term pinealectomy in the rat suprachiasmatic nuclei and pars tuberalis
Author(s) -
Gauer François,
MassonPévet Murielle,
Pévet Paul
Publication year - 1994
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1994.tb00085.x
Subject(s) - pinealectomy , pars tuberalis , melatonin , endocrinology , medicine , melatonin receptor , receptor , pinealocyte , biology , pineal gland , chemistry , pituitary gland , hormone
Gauer F, Masson‐Pévet M, Pévet P. Differential regulation of melatonin receptors by short‐ versus long‐term pinealectomy in the rat suprachiasmatic nuclei and pars tuberalis. J. Pineal Res. 1994: 16: 73–76. Abstract We have investigated the effects of short‐ and long‐term pinealectomy on the density of melatonin receptors in both the suprachiasmatic nuclei (SCN) and pars tubercles (PT) of the rat. Short‐term pinealectomy (conducted 3‐5 days before sacrifice) induced a significant increase in the density of melatonin receptors in both structures. This increase can be interpreted as an up‐regulation of melatonin receptors following the absence of plasma melanoma. In contrast, 7 days after pinelectomy, the receptor density began to decrease, reaching a low point 1. 5 months after pinealectomy. At this time, the decrease represents a 40‐45% reduction in binding sites as compared with values measured 3–5 days after pinealectomy. This slow decrease could be related to a slowdown of melatonin receptor synthesis. These results suggest that emblazoning has a stimulatory effect on its own receptor synthesis. However, at 1. 5 months after pinealectomy a novel equilibrium between synthesis and hydrolysis seems to be reached. Melanoma does not appear to be indispensable for the synthesis of its receptors.