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Distribution of cholinergic and dopaminergic receptors in rainbow trout pineal gland
Author(s) -
Samejima Michikazu,
Happe H. Kevin,
Murrin L. Charles,
Pfeiffer Ronald F.,
Ebadi Manuchair
Publication year - 1994
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1994.tb00080.x
Subject(s) - medicine , endocrinology , dopaminergic , pineal gland , muscarinic acetylcholine receptor , receptor , biology , cholinergic , dopamine receptor , nicotinic agonist , rainbow trout , dopamine , melatonin , fishery , fish <actinopterygii>
Samejima M, Happe HK, Murrin LC, Pfeiffer RE, Ebadi M. Distribution of cholinergic and dopaminergic receptors in rainbow trout pineal gland. J. Pineal Res. 1994: 16: 37–43. Abstract The involvement of multiple receptors in modulating the function of the pineal gland was investigated by searching for dopaminergic and cholinergic receptors in trout pineal gland. Dopamine D 1 and D 2 receptors were measured using [ 3 H]SCH23390 and [ 3 H]spiperone, respectively. Muscarinic and nicotinic cholinergic receptors were measured using quinuclidinyl benzilate ([ 3 H]QNB) and [ 3 H]methylcarbamyl choline, respectively. High‐affinity choline uptake sites were measured using [ 3 H]hemicholinium‐3. The distribution of dopaminergic receptors varied throughout the pineal gland in that the density of D 2 receptors, which was higher than that of D 1 receptors, was most abundant in the distal region, exhibiting a value of 112 ± 17 fmol/mg tissue. The distribution of both muscarinic and nicotinic receptors was uniform throughout the pineal gland. However, the highest value for the high‐affinity choline transporter (106 ± 17 fmol/mg tissue) occurred in the proximal portion of the trout pineal gland. The results of these studies indicate that the pineal gland should not be viewed as a homogenous tissue possessing identical density of various receptors. Furthermore, these results, along with previous data, are interpreted to suggest that different regions of pineal gland may indeed possess unique functions.