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Influence of melatonin on the proliferation of hepatoma cells in the Syrian hamster: In vivo and in vitro study
Author(s) -
Karasek M.,
Liberski P.,
KunertRadek J.,
Bartkowiak J.
Publication year - 1992
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1992.tb00063.x
Subject(s) - melatonin , in vivo , in vitro , hamster , endocrinology , biology , medicine , cell growth , biochemistry , microbiology and biotechnology
A study was carried out to determine the possible influence of melatonin on the proliferation of Kirkman‐Robbins hepatoma cells in Syrian hamsters, both in vivo and in vitro. A highly significant inhibition of the proliferation of transplanted hepatoma cells was observed in vivo following melatonin administration (proliferation index 10.3 ± 1.5; mean ± SD) in comparison with controls (proliferation index 23.3 ± 2.2), whereas in vitro melatonin (at concentrations of 10 −5 ‐10 −11 M) was ineffective. These results indicate that inhibitory effect of melatonin on transplantable hepatoma cells in vivo may be indirect.