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The importance of timing in melatonin administration in a blind man
Author(s) -
Tzischinsky Orna,
Pal Itzhak,
Epstein Rachel,
Dagan Yaron,
Lavie Peretz
Publication year - 1992
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1992.tb00035.x
Subject(s) - melatonin , bedtime , circadian rhythm , medicine , regimen , somnolence , sleep (system call) , dark therapy , endocrinology , psychology , adverse effect , computer science , operating system
An 18‐year‐old blind man suffered from chronic sleep disturbances associated with daytime fatigue and excessive daytime somnolence. After two unsuccessful treatment regimens with 5 mg and 10 mg melatonin administered at bedtime (2200–2230), a third regimen of 5 mg melatonin administered at 2000 for 3 weeks resulted in a successful resolution of his sleep disturbances. We suggest that the efficacy of melatonin in ameliorating sleep disturbances because of alterations in circadian rhythmicity may be dependent on the time of administration.