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Melatonin, pinealectomy, and release of neurohypophysial hormones: In vitro studies
Author(s) -
Juszczak Marlena,
Stempniak Bozena,
Guzek Jan W.
Publication year - 1992
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1992.tb00019.x
Subject(s) - melatonin , pinealectomy , vasopressin , medicine , oxytocin , endocrinology , neuropeptide , biology , basal (medicine) , pineal gland , chemistry , receptor , insulin
The effect of melatonin as well as pinealectomy on the basal and K + ‐evoked release of vasopressin and oxytocin from the neurointermediate lobes in vitro was determined. Pineal removal resulted in a diminution of vasopressin and oxytocin release from the neurointermediate lobes in vitro. Melatonin (10 −3 or 10 −6 M/1) increased vasopressin and oxytocin release from neurointermediate lobes of sham‐operated rats. Nevertheless, when pinealectomized rats served as donors of the neurointermediate lobes, melatonin (10 −3 or 10 −6 M/1) increased vasopressin release under basal conditions. For the same tissue, melatonin did not affect the oxytocin release either under basal conditions or during depolarization due to excess potassium. When 10 −7 M/l melatonin was used, no changes in either vasopressin or oxytocin release were observed in vitro.