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Adenosine effects on the rat pineal gland in vitro: Cyclic adenosine monophosphate levels, N‐acetyltransferase, and thyroxine type II 5′‐deiodinase activities and melatonin production
Author(s) -
aka K.O.,
Reiter R.J.,
Withyachumnarnkul B.,
Stokkan KA.,
Lerchl A.
Publication year - 1991
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1991.tb00819.x
Subject(s) - medicine , endocrinology , pineal gland , adenosine , melatonin , agonist , biology , deiodinase , receptor , chemistry , thyroid , triiodothyronine
The presence of adenosine and its receptors in the pineal gland suggests that they could have a regulatory influence on pineal physiology. Rat pineal glands cultured in the presence of the adenosine analog 5′‐N‐ethylcarboxamido adenosine (NECA) promoted a significant increase in pineal adenosine 3′5′‐monophosphate (cAMP) content, similar to that caused by the ß‐adrenergic receptor agonist isoproterenol (ISO). A potentiation of the cAMP response occurred when the glands were simultaneously stimulated with both NECA and ISO. Whereas high cAMP levels induced by ISO were associated with an increased N‐acetyltransferase (NAT) activity and rise in the melatonin production and release, the NECA‐induced rise in cAMP concentration failed to promote an increase in the activity of either NAT or another pineal enzyme thyroxine 5′‐deiodinase type II; likewise, pineal melatonin levels did not rise.