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Chronic Administration of Pineal Peptides Change the Circadian Locomotor Activity and Time‐Course of Forced Swimming in Rats
Author(s) -
Arushanian Edward B.,
Baturin Vladimir A.,
Ovanesov Karen B.
Publication year - 1990
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1990.tb00902.x
Subject(s) - circadian rhythm , melatonin , endocrinology , medicine , locomotor activity , rhythm , pineal gland , period (music) , biology , physics , acoustics
After chronic administration of epithalamin (a pineal peptide drug), an increase in the amplitude and shifts in the acrophase of rat's circadian locomotor activity to late hours were observed. These results were obtained only in rats with low initial amplitude of their circadian rhythm. Epithalamin also changed the time‐course of forced swimming and decreased the rhythmic index of depression. These observations suggest that the pineal gland of the rat, via its peptides, may prevent the development of depressive‐like events.