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Antigonadal Activity of the Melatonin Analogs 2‐Iodomelatonin and 2‐Chloromelatonin in the Juvenile Djungarian Hamster, Phodopus sungorus campbetti
Author(s) -
Sugden David
Publication year - 1989
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1989.tb00668.x
Subject(s) - melatonin , phodopus , hamster , endocrinology , medicine , potency , juvenile , biology , photoperiodism , body weight , in vitro , biochemistry , genetics
The antigonadal effects of daily (20 (μg, s.c.) injection of melatonin and two analogs, 2‐iodomelatonin and 2‐chloromelatonin, were compared in juvenile Djungarian hamsters housed under long photoperiod (L:D 16:8). Melatonin, 2‐iodomelatonin, and 2‐chloromelatonin injected 3h before lights off for 16 days (17–34 days of age) significantly inhibited testis growth compared to vehicle‐injected hamsters. In addition, melatonin and both analogs significantly reduced body weight gain. These 2‐substituted analogs appear to be melatonin agonists with a potency in vivo similar to the parent compound, melatonin.