Premium
Dynamic Uptake of Radioactive Substance in Rat Salivary Gland Following 3 H‐Melatonin Administration
Author(s) -
Withyachumnarnkul Boonsirm,
Wongprapairot Pornpimol,
Trakulrungsi Wantanee
Publication year - 1987
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1987.tb00853.x
Subject(s) - melatonin , medicine , endocrinology , salivary gland , pineal gland , hormone , kidney , biology , chemistry
Dynamics of radioactive accumulation in rat greater salivary glfollowing systemic administration of 3 H‐melatonin was studied to determine a possible action of the hormone in the gland. Progressive decline of 3 H‐melatonin concentrations was found in the serum, lung, skeletal muscle, liver, kidney, salivary glduring 60 min following the administration. On the contrary, there was a progressive accumulation of radioactive substance other than 3 H‐melatonin in the salivary glbut not in other tissues mentioned. The radioactivity was also progressively preferentially localized in the nuclear fraction of the glcells. These results suggest a possible direct action of melatonin derivative in rat salivary gland.