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Effect of Various Cations on the Activity of Pineal Gland N‐Acetyltransferase (EC 2.3.1.5) and Hydroxyindole‐O‐Methyl Transferase (EC2.1.1.4) In Vitro
Author(s) -
Morton Dougal J.
Publication year - 1987
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1987.tb00852.x
Subject(s) - pineal gland , n acetyltransferase , chemistry , potassium , calcium , in vitro , nat , melatonin , sodium , medicine , transferase , methyltransferase , endocrinology , biochemistry , choline acetyltransferase , enzyme , cholinergic , biology , acetylation , methylation , organic chemistry , computer network , computer science , gene
The effect of various cations on activity of hydroxyindole‐O‐methyltransferase (HIOMT) and N‐acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechansims of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, and sodium initially stimulated NAT activity, and as the cation concentration increased inhibitory activity was observed. These differential effects on NAT activity may in some way be involved in pineal regulation of cation levels.