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Effects of Pineal Indoles and Arginine Vasotocin on Lipolysis and Lipogenesis in Isolated Adipocytes
Author(s) -
Ng T. B.,
Wong C. M.
Publication year - 1986
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1986.tb00726.x
Subject(s) - lipolysis , lipogenesis , medicine , endocrinology , vasotocin , melatonin , chemistry , biology , basal (medicine) , adipose tissue , neuropeptide , insulin , receptor
The effects of arginine vasotocin and the pineal indoles melatonin, serotonin, Nacetylserotonin, hydroxytryptophol, methoxytryptophol, hydroxyindoleacetic acid, methoxyindoleacetic acid, and methoxytryptamine on lipolysis and lipogenesis in isolated adipocytes were studied. Basal lipolysis was inhibited by all the indoles tested at a dose of I μmole except hydroxytryptophol. Methoxytryptamine and serotonin inhibited hormone‐induced lipolysis in a dosedependent manner and exhibited the highest antilipolytic activity in isolated rat, rabbit, and hamster adipocytes. However, their antilipolytic activity could not be overcome by increasing the dose of the lipolytic hormone. Dibutyryl cyclic AMP‐induced lipolysis was also inhibited. All the pineal indoles tested were capable of suppressing basal and insulin‐stimulated lipogenesis in the dose range 0.33–3 nmole. At lower doses there was no effect. Arginine vasotocin at a dose of 25 nmole significantly augmented basal lipogenesis.