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Pineal‐Induced Depression of Free Thyroxine in Syrian Hamsters
Author(s) -
Vaughan George M.,
Pruitt Basil A.
Publication year - 1985
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1985.tb00713.x
Subject(s) - pinealectomy , medicine , endocrinology , melatonin , free fraction , pineal gland , free thyroxine , blinding , biology , thyroid , randomized controlled trial , thyroid function , pharmacokinetics
Blind hamsters had no alteration of the dialyzable fraction of serum thyroxine (T4) but had depressed total and free T4 concentrations compared to controls. Prevention of the effects of blinding by pinealectomy indicates pineal influence on circulating free T4 concentration. Parallel changes in free T4 and the free T4 index indicate adequacy of the index in representing pineal‐induced changes in free T4.