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Distribution of Substance P Neurons in the Epithalamus of the Rat: An Immunohistochemical Investigation
Author(s) -
Rønnekleiv Oline K.,
Kelly Martin J.
Publication year - 1984
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1984.tb00226.x
Subject(s) - habenula , substance p , immunohistochemistry , biology , anatomy , cervical ganglia , neuropeptide , endocrinology , central nervous system , medicine , immunology , biochemistry , receptor
Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase‐antiperoxidase immunocytochemical technique. Cells containing immunoreactive SP were located in the medial habenula, and SP fibers were observed in the lateral habenula, habenular commissure, pineal stalk, and the pineal organ. Bilateral removal of the superior cervical ganglia did not affect the immunocytochemical staining of SP‐containing cells and fibers 15–30 days later. It is suggested that habenular neurons containing SP send projections into the pineal organ of the rat.