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Differential Effect of Carbidopa on the Concentration of Rat Pineal and Hypothalamic Indoleamines
Author(s) -
Oxenkrug Gregory F.,
Mclntyre Iain M.,
Novak Edward A.,
Hryhorczuk Lew M.,
Frohman Charles E.
Publication year - 1984
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1984.tb00225.x
Subject(s) - carbidopa , melatonin , serotonin , aromatic l amino acid decarboxylase , decarboxylation , 5 hydroxytryptophan , endocrinology , medicine , chemistry , 5 hydroxyindoleacetic acid , pineal gland , pharmacology , levodopa , dopamine , biochemistry , biology , receptor , disease , parkinson's disease , catalysis
Carbidopa, an aromatic acid decarboxylase inhibitor, has been shown to significantly decrease the pineal concentration of melatonin, N‐acetyl serotonin (NAS), serotonin (5‐HT), and 5‐hydroxyindoleacetic acid (5‐HIAA) but not the hypothalamic concentrations of these indoles. Increased levels of 5‐hydroxytryptophan (5‐HTP) indicate that carbidopa directly inhibits 5‐HTP decarboxylation, thus limiting 5‐HT production. Possible practical implications of selective inhibition of pineal indoleamines by carbidopa are discussed.