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Melatonin Inhibits Prostaglandin E Release From the Medial Basal Hypothalamus of Pinealectomized Rats
Author(s) -
Pawlikowski Marek,
Juszczak Marlena,
Karasek Ewa,
Muszyǹska Barbara,
Karasek Michal
Publication year - 1984
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1984.tb00222.x
Subject(s) - pinealectomy , melatonin , medicine , hypothalamus , endocrinology , basal (medicine) , prostaglandin , pineal gland , chemistry , prostaglandin e , biology , insulin
The effects of pinealectomy and of melatonin administration on prostaglandin E synthesis in the medial basal hypothalamus were studied in male rats. Melatonin treatment significantly decreased prostaglandin E release from the medial basal hypothalamus in pinealectomized rats. The results of the present study suggest that melatonin modulates hypothalamo‐hypophyseal function, at least in part, via inhibition of hypothalamic prostaglandin synthesis.