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Electroconvulsive Shock: Effect on Pineal and Hypothalamic Indoles
Author(s) -
McIntyre Iain M.,
Oxenkrug Gregory F.
Publication year - 1984
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1984.tb00218.x
Subject(s) - melatonin , serotonergic , antidepressant , electroconvulsive shock , electroconvulsive therapy , serotonin , medicine , endocrinology , hypothalamus , receptor , psychology , hippocampus
Chronic electroconvulsive shock (ECS) did not significantly alter pineal concentrations of melatonin. Statistically significant decreases of serotonin, however, were found in both the pineal and hypothalamus. These results support the previous reports of serotoninergic receptor supersensitivity following repeated ECS, and suggest serotoninergic involvement but do not necessarily exclude adrenergic involvement in the antidepressant effect of electroconvulsive therapy.