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Pinealectomy Has No Effect on Diet‐Induced Thermogenesis and Brown Adipose Tissue Proliferation in Rats
Author(s) -
Viswanathan Mohan,
George John C.
Publication year - 1984
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/j.1600-079x.1984.tb00196.x
Subject(s) - pinealectomy , brown adipose tissue , thermogenesis , endocrinology , medicine , thermoregulation , pineal gland , biology , adipose tissue , cafeteria , melatonin , white adipose tissue , pathology
The role of the pineal gland in diet‐induced thermogenesis (DIT) and growth of brown adipose tissue (BAT) in rats during voluntary overfeeding was studied using pinealectomized and sham‐pinealectomized rats. Overfeeding was induced by offering the animals a cafeteria‐diet (CD) which contained a selection of highly palatable food items. Rats which were fed CD had significantly increased interscapular brown adipose tissue (IBAT) mass and increased tail‐skin temperature indicating the importance of the tail in thermoregulation during DIT. Pinealectomy had no effect on the increase in tail‐skin temperature and deposition of IBAT, which were stimulated by CD feeding. These findings suggest that the pineal is not directly involved in modulating the metabolism of BAT in rats.