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The impact of ultraviolet therapy on stratum corneum ceramides and barrier function
Author(s) -
Jungersted Jakob Mutanu,
Høgh Julie K.,
Hellgren Lars I.,
Jemec Gregor B. E.,
Agner Tove
Publication year - 2011
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2011.00618.x
Subject(s) - stratum corneum , barrier function , ceramide , psoriasis , dermatology , ultraviolet light , ultraviolet , skin barrier , chemistry , corneocyte , biophysics , medicine , materials science , pathology , biochemistry , photochemistry , biology , microbiology and biotechnology , optoelectronics , apoptosis
Summary The ceramide profile as well as the barrier function is known to be deteriorated in atopic eczema and psoriasis, and ultraviolet ( UV ) light is known to improve the barrier function. The impact of UV light on ceramides, however, is not clarified. The aim of this study was to examine the effect of UV therapy in dermatological patients on ceramides and skin barrier function. We found that UV light treatment does not change the ratio of important stratum corneum lipids, but we confirm earlier findings of decreased susceptibility to irritants after UV ‐ therapy.