Premium
Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide
Author(s) -
Masuoka Eriko,
Bito Toshinori,
Shimizu Hideki,
Nishigori Chikako
Publication year - 2011
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2011.00614.x
Subject(s) - hydrochlorothiazide , discontinuation , photosensitivity , medicine , dermatology , melanin , melanocyte , drug , tacrolimus , pharmacology , chemistry , cancer research , melanoma , biochemistry , physics , transplantation , quantum mechanics , blood pressure
Summary We report a 68‐year‐old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin‐positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug‐induced photoleukomelanoderma.