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Complete resolution of a squamous cell carcinoma of the skin using intralesional 5‐aminolevulinic acid photodynamic therapy intralesional PDT for SCC
Author(s) -
Sotiriou Eleni,
Apalla Zoi,
Ioannides Demetris
Publication year - 2010
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2010.00531.x
Subject(s) - photodynamic therapy , medicine , basal cell , dermatology , skin cancer , complete response , surgery , cancer , pathology , chemotherapy , chemistry , organic chemistry
We present an 82‐year‐old female patient with a 2‐year history of an infiltrative squamous cell carcinoma (SCC) on her right cheek. The patient was treated with one intralesional photodynamic therapy (PDT) session using 10% 5‐aminolevulinic acid solution. We used red light by a non‐coherent light source at a light dose of 100 J/cm 2 and a fluency rate of 100 mW/cm 2 . Complete clinical and histological response was achieved 3 months after the treatment procedure. Cosmetic outcome was evaluated as fair. The patient remains disease free with the absence of any clinical sign of recurrence 16 months after PDT. Long‐term follow‐up is needed for assessment of recurrences. Optimization of the therapeutic protocol, as well as justification of our results in larger studies are needed in order to elicit safe conclusions.