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Preferential induction of endothelin‐1 in a human epidermal equivalent model by narrow‐band ultraviolet B light sources
Author(s) -
Noborio Reiko,
Morita Akimichi
Publication year - 2010
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2010.00510.x
Subject(s) - ultraviolet b , vitiligo , excimer laser , ultraviolet , excimer , xenon , irradiation , ultraviolet light , chemistry , dermatology , laser , materials science , optoelectronics , photochemistry , medicine , optics , physics , organic chemistry , nuclear physics
Narrow‐band ultraviolet B (NB‐UVB; 310–315 nm) is commonly used to treat vitiligo, but the mechanisms underlying the therapeutic effect have not been understood completely. Here, we evaluated the effects of broadband UVB (BB‐UVB), NB‐UVB, 308 nm xenon chloride (XeCl) excimer laser, and 308 nm XeCl excimer light on the expression of endothelin‐1 (ET‐1) in a cultured human epidermal tissue model. Our results provide a theoretical basis for the effectiveness of UVB irradiation, including excimer light and excimer laser, in the treatment of vitiligo.