Premium
Prevention of scattered light‐induced asthenopia and fatigue by a polarized filter
Author(s) -
Hiramoto Keiichi,
Yamate Yurika,
Orita Kumi,
Jikumaru Mika,
Kasahara Emiko,
Sato Eisuke F.,
Tamura Shinzo,
Inoue Masayasu
Publication year - 2010
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2010.00497.x
Subject(s) - irradiation , endocrinology , medicine , secretion , white light , optics , chemistry , physics , nuclear physics
Background: It has been well documented that a long‐time irradiation of the eye by a strong light elicits eyestrain and fatigue. To elucidate the mechanism for the induction of light‐induced fatigue and asthenopia, changes in the mouse were analyzed after white light‐irradiation to the eye. Methods: C57BL/6j male mice were irradiated with white light in a specially designed room equipped with four mirrors covering all areas of its four walls to elicit diffused reflected light, and changes in their plasma levels of cortisol, INF‐γ, interleukin‐10 (IL‐10) and transforming growth factor‐β (TGF‐β) were analyzed. Results: Irradiation of mice with scattered white light significantly decreased the motional activity of animals, suggesting the occurrence of fatigue. Biochemical analysis and enzyme‐immunoassay revealed that the irradiation of mice significantly elevated the plasma levels of cortisol, IFN‐γ, IL‐10 and TGF‐β. All these changes were not observed with mice irradiated with the light in a similar room not equipped with mirrors. These changes were successfully inhibited by a polarized glass filter but not by a non‐polarized filter with a similar absorbance. Coclusions: These observations suggest that irradiation of the eye by scattered reflected light stimulated a stress response via hypothalamo‐pituitary‐adrenal axis to enhance the secretion of cortisol from the adrenal grand and increase the plasma levels of cytokines.