Premium
Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system
Author(s) -
Zawislak Agnieszka A.,
McCluggage William G.,
Donnelly Ryan F.,
Maxwell Peter,
Price John H.,
Dobbs Stephen P.,
McClelland H. Raymond,
Woolfson A. David,
Mccarron Paul A.
Publication year - 2009
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2009.00410.x
Subject(s) - photodynamic therapy , bioadhesive , lichen sclerosus , medicine , hyperplasia , dermatology , pathological , pathology , drug delivery , chemistry , organic chemistry
This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm 2 ) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post‐treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA‐PDT patch‐based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.