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Tumour necrosis factor α (TNF‐α)‐converting enzyme (TACE) and soluble TNF‐α receptor type 1 in psoriasis patients treated with narrowband ultraviolet B
Author(s) -
Serwin Agnieszka Beata,
Sokolowska Marianna,
Chodynicka Bozena
Publication year - 2007
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2007.00296.x
Subject(s) - psoriasis , medicine , psoriatic arthritis , psoriasis area and severity index , tumor necrosis factor alpha , peripheral blood mononuclear cell , gastroenterology , necrosis , immunology , chemistry , biochemistry , in vitro
Purpose: The aim of the study was to examine the tumour necrosis factor α (TNF‐α)‐converting enzyme (TACE) concentration in peripheral blood mononuclear cells (PBMC) and its relationship with plasma concentration of soluble TNF‐α receptor type 1 (sTNF‐R1) and with the disease severity in psoriasis patients treated with narrowband ultraviolet B (NB‐UVB). Methods: The study has been conducted among 40 patients with plaque‐type psoriasis vulgaris: 23 had only skin lesions (PV) and 17 had co‐existing, inactive, psoriatic arthritis (PsA). Control blood samples were obtained from 20 healthy subjects. The assessment of the severity of skin lesions (using Psoriasis Area and Severity Index – PASI), TACE and sTNF‐R1 concentrations (using quantitative sandwich enzyme immunoassays) have been performed at baseline (T 0) and after 20 NB‐UVB irradiations (T 20). Results: The baseline sTNF‐R1 and TACE concentrations in all patients was higher than that in controls (2.55 ± 1.67 vs. 1.70 ± 0.15 ng/ml, P <0.001, respectively, and 2.62 ± 0.32 vs. 1.31 ± 0.30 ng/ml, P <0.001, respectively). The sTNF‐R1 and TACE concentrations were lower in PV than in PsA patients (2.47 ± 0.16 vs. 2.65 ± 0.13 ng/ml, and 2.52 ± 0.22 vs. 2.76 ± 0.39 ng/ml, P <0.05, respectively). The baseline PASI correlated with sTNF‐R1 and to TACE concentrations ( R =0.48 and 0.39, P <0.05, respectively). The sTNF‐R1 correlated to TACE concentration ( R =0.52, P <0.05). The significant decline in sTNF‐R1 and TACE concentrations at T 20 was noticed, TACE reached control values (1.20 ± 0.44 ng/ml in PV patients and 1.16 ± 0.48 ng/ml in PsA patients, respectively). Conclusion: TACE from PBMC can contribute to up‐regulation of sTNF‐R1 in patients with active psoriasis vulgaris and with psoriatic arthritis. It also can serve as a sensitive marker of the disease severity.