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The characteristics of erythema induced by topical 5‐aminolaevulinic acid photodynamic therapy
Author(s) -
Clark Colin,
Dawe Robert S,
Moseley Harry,
Ferguson James,
Ibbotson Sally H.
Publication year - 2004
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.2004.00085.x
Subject(s) - phototoxicity , photodynamic therapy , erythema , dermatology , medicine , chemistry , biochemistry , organic chemistry , in vitro
Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non‐melanoma skin cancers. Knowledge of the characteristics of 5‐aminolaevulinic acid (ALA)‐induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes. Methods: We examined the characteristics of ALA‐induced erythema in 10 healthy subjects and investigated the effect of light source and body site. Results and Conclusion: Maximal erythema occurred within 1–2 h of PDT and inter‐individual variation in ALA‐induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non‐coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.