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Xeroderma pigmentosum variant associated with multiple cancers
Author(s) -
Kuwamoto K.,
MiyauchiHashimoto H.,
Isei T.,
Horio T.
Publication year - 1999
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.1999.tb00072.x
Subject(s) - xeroderma pigmentosum , photodermatosis , erythema , melanoma , cancer research , basal cell carcinoma , basal cell , skin cancer , medicine , dermatology , cell , dna damage , dna , biology , pathology , cancer , genetics
A 62‐year‐old Japanese man with xeroderma pigmentosum (XP) variant is reported. The patient had developed at least 6 basal cell carcinomas, a squamous cell carcinoma, and a malignant melanoma on sun‐exposed areas, and an atypical carcinoid on the right lung. In vivo phototesting showed a normal response. The minimal erythema dose of ultraviolet B (UVB) was not lowered and no delayed peaking of the erythema reaction was observed. His skin fibroblasts exhibited higher sensitivity to UV irradiation, but a normal level of unscheduled DNA and RNA synthesis. Cell fusions with XP group A, C, D, E, F, and G cells after UV irradiation were all complemented. Previous reports together with this case suggest that older XP variant patients have a high frequency of not only skin cancers, but also internal malignancies.