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Effects of water temperature on photosensitization in bath‐PUVA therapy with 8‐methoxypsoralen
Author(s) -
Gruss C.,
Behrens S.,
Kobyletzki G.,
Reuther T.,
Husebo L.,
Altmeyer P.,
Kerscher M.
Publication year - 1998
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.1998.tb00032.x
Subject(s) - psoralen , phototoxicity , puva therapy , methoxsalen , chemistry , pharmacokinetics , adverse effect , dermatology , pharmacology , medicine , psoriasis , biochemistry , dna , in vitro
The pharmacokinetic aspects of bath‐PUVA are not completely clarified. Therefore, we determined the phototoxic response of human skin following psoralen baths at temperatures ranging from 32°C to 42°C (71.6–107.6°F) and UVA doses ranging from 0.5 to 5.5 J/cm 2 . The highest therapeutical photosensitization (i.e., lowest minimal phototoxic dose) was assessed at temperatures of 37°C (98.6°F) and above. Photosensitization was significantly decreased at lower temperatures. These data indicate that a bath temperature of 37°C (98.6°F) should be used to gain optimal therapeutic efficiency in a clinical setting. Furthermore, in order to minimize the risk of adverse phototoxic effects in bath‐PUVA, it is important to use a constant temperature during the psoralen bath.