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Phototesting in bath‐PUVA: marked reduction of 8‐methoxypsoralen (8‐MOP) activity within one hour after an 8‐MOP bath
Author(s) -
Schempp C. M.,
Schöpf E.,
Simon J. C.
Publication year - 1996
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.1996.tb00184.x
Subject(s) - erythema , puva therapy , dermatology , photosensitivity , methoxsalen , chemistry , medicine , optics , psoriasis , physics
It is not known how long after 8‐MOP bath‐PUVA administration erythema can be induced. Therefore, after determination of dose‐dependence and kinetics of bath‐PUVA erythema, we investigated the development of erythema using an erythematogenic UVA‐dose (3 J/cm 2 ) in time course experiments. Our results show that there is a loss of biological 8‐MOP activity already 1 h after 8‐MOP bath. This has important consequences for clinical practice with bath‐PUVA, concerning the optimum time interval between the 8‐MOP bath and irradiation as well as the persistence of photosensitivity in normal skin after bath‐PUVA.