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Phototoxic and photoprotective effects of topical isothipendyl
Author(s) -
Moreau A.,
Dompmartin A.,
Dubreuil A.,
Leroy D.
Publication year - 1995
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/j.1600-0781.1995.tb00139.x
Subject(s) - phototoxicity , photoprotection , chemistry , dermatology , traditional medicine , medicine , biochemistry , in vitro , photosynthesis
Isothipendyl, an H1‐receptor antagonist, is an antihistamince used as an antiallergic drug. Its molecular structure is close to the phenothiazines, but it has different photobiological properties. Like phenothiazines, isothipendyl is phototoxic with ultraviolet A (UVA) but it reduces the erythema response to UVB radiation. Isothipendyl seems to have the same protective properties as a sunscreen because its UVB protective properties are effective only if the substance is applied prior to exposure.