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Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats
Author(s) -
Guimarães R. P.,
de Oliveira P. A. D.,
Oliveira A. M. S. D.
Publication year - 2011
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.2011.01391.x
Subject(s) - medicine , diabetes mellitus , implant , endocrinology , analysis of variance , saline , surgery
Guimarães RP, de Oliveira PAD, Oliveira AMSD. Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats. J Periodont Res 2011; 46: 691–696. © 2011 John Wiley & Sons A/S Background and Objective: The present study aimed to assess the effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants in rats. Material and Methods: Thirty‐six rats were randomly divided into six groups: group 1, healthy rats (no aminoguanidine); group 2 and group 3, healthy rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively; group 4, diabetic rats (no aminoguanidine); and group 5 and group 6, diabetic rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively. In each rat an implant was inserted in the femur. After 28 d of healing, the rats were killed. The implants were removed by applying a counter‐torque, and the maximum force required for the rupture of the bone–implant interface was recorded using an analog torque meter. The data were evaluated using analysis of variance and the Student’s t ‐test. Results: In the healthy groups, no statistically significant difference could be observed in the average counter‐torque values for implant removal, whereas in the diabetic groups, a daily dose of 20 mg/kg of aminoguanidine raised the counter‐torque values to the values found in healthy rats. Conclusion: The administration of 20 mg/kg of aminoguanidine daily in diabetic rats raised the biomechanical retention of the implants to the level observed in the healthy rat group.