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Single nucleotide polymorphisms of complement component 5 and periodontitis
Author(s) -
Chai L.,
Song Y.Q.,
Zee K.Y.,
Leung W. K.
Publication year - 2010
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.2009.01234.x
Subject(s) - periodontitis , single nucleotide polymorphism , haplotype , linkage disequilibrium , snp , genotype , population , genetics , medicine , biology , gene , environmental health
Chai L, Song Y‐Q, Zee K‐Y, Leung WK. Single nucleotide polymorphisms of complement component 5 and periodontitis. J Periodont Res 2010; 45: 301–308. © 2009 John Wiley & Sons A/SBackground and Objective: Polymorphisms of host defence genes might increase one’s risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. Material and Methods: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i‐plexGOLD MassARRAY mass‐spectrometry system. Results: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model ( p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis ( p = 0.006). Conclusion: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.