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Systemic manifestations of periodontitis in the non‐human primate
Author(s) -
Ebersole J. L.,
Cappelli D.,
Mott G.,
Kesavalu L.,
Holt S. C.,
Singer R. E.
Publication year - 1999
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1999.tb02266.x
Subject(s) - periodontitis , haptoglobin , acute phase protein , fibrinogen , gingivitis , immunology , medicine , inflammation , bacteroidaceae , biology , bacteria , dentistry , genetics
This report describes our findings regarding the potential contribution of periodontitis to atherosclerotic processes using a nonhuman primate model. The goal of the investigations was to target general mechanisms which could describe the association of these disease processes, including: (i) systemic translocation of bacteria/products during periodontitis; (ii) alterations in systemic inflammatory biomarkers during periodontitis; and (iii) the relationship of periodontitis to serum lipids /lipoproteins. Increases in serum endotoxin (e.g. LPS) during ligature‐induced periodontitis were observed in these animals. We determined serum levels of various acute phase reactants and chemokines (e.g. CRP. α 1 ‐antitrypsin, haptogiobin, fibrinogen, IL‐8). A number of these host factors were significantly increased during gingivitis and/or periodontitis. Finally, we observed specific changes in serum lipid levels (cholesterol, triglycerides, HDL, LDL) and lipoproteins (apoA‐I) during periodontitis, which were exacerbated by exposure of the animals to a diet with elevated fat content. Thus, we have described systemic manifestations of periodontitis that include detection of bacterial products, inflammatory biomarkers, and dyslipoproteinemia consistent with an increased atherogenic risk.