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Interleukin‐1 genotypes and the association between periodontitis and cardiovascular disease
Author(s) -
Kornman Kenneth S.,
Pankow James,
Offenbacher Steven,
Beck James,
Giovine Francesco,
Duff Gordon W.
Publication year - 1999
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1999.tb02265.x
Subject(s) - periodontitis , disease , genotype , medicine , genetic association , periodontal disease , interleukin , aggressive periodontitis , bioinformatics , pathology , immunology , gene , biology , genetics , single nucleotide polymorphism , cytokine
An epidemiological association between periodontitis and cardiovascular disease has been reported in multiple studies. Various mechanisms have been proposed as potential explanations for this association, including a common factor that predisposes certain individuals to a hyper‐responsive inflammatory response. Variations in the genes that regulate the interleukin‐1 (IL‐1) response have been associated with both periodontal disease and cardiovascular disease. New data indicate that one pattern of IL‐1 genetic polymorphisms, characterized by the IL‐1 A (+ 4845) and IL‐1 B (+ 3954) markers, is associated with periodontitis but not certain measures of atherosclerosis. Another IL‐1 genetic pattern, characterized by the IL‐1 B (‐511) and IL‐1RN (+ 2018) markers, is associated with atherosclerotic plaque formation, as measured by angiography and arterial wall thickness, but not periodontitis. These two patterns also have different functional implications relative to IL‐1 biological activity. Studies of IL‐1 gene polymorphisms, atherosclerotic plaque instability and cardiovascular clinical events are in progress. Hypothetical models are presented to explain how IL‐1 genetic factors may be involved in cardiovascular disease.