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Type VI collagen is associated with microfibrils and oxytalan fibers in the extracellular matrix of periodontium, mesenterium and periosteum
Author(s) -
Everts V.,
Niehof A.,
Jansen D.,
Beerken W.
Publication year - 1998
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1998.tb02300.x
Subject(s) - elastin , periosteum , extracellular matrix , chemistry , type i collagen , periodontal fiber , anatomy , collagen, type i, alpha 1 , connective tissue , periodontium , matrix (chemical analysis) , fibril , biophysics , pathology , biology , dentistry , biochemistry , medicine , chromatography
Type VI collagen was immunolocalized in several soft connective tissues at the light and electron microscopic level. Positive labeling was found in all tissues examined, periodontal ligament, gingiva, mesenterium and periosteum. The labeled structures could be divided into 2 categories: microfibrils intermingling with collagen fibrils, and those that formed bundles (oxytalan fibres and elastin‐associated microfibrils). Control sections incubated with antibody pre‐absorbed to purified type VI collagen, or with non‐immune antibody, proved to be negative. Our observations indicate that the structural organization of type VI collagen varies from small microfibrillar structures associated with the collagen and elastin fibre systems to highly ordered parallel arrays of oxytalan bundles.