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Localization and quantification of TXB 2 in human healthy and inflammatory gingival mucosa
Author(s) -
SonsSicard C.,
Choquet A.,
Escola R.
Publication year - 1998
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1998.tb02288.x
Subject(s) - gingivitis , periodontitis , thromboxane , pathology , medicine , dentistry , platelet
We conducted a study to localize and quantify the thromboxane B, (TXB 2 ) in human gingival tissue obtained from clinically healthy sites and patients with gingivitis and periodontitis. Human gingival samples were assayed for TXB 2 by immunofluorescence on slides and enzyme‐immunoassay (EIA). We found that concentrations of TXB 2 in gingivitis sites are at mean 10‐fold higher than in the healthy sites and histologically show a consistently intracytoplasmic staining with a significant increase in gingivitis. This argues in favour of a local production of TXB 2 . Concentrations of TXB 2 at periodontitis sites are only 3‐fold higher than in healthy sites and histologically show a stronger staining as for the gingivitis sections, with principally an extracellular localization. Thus, TXB 2 could be released in large quantities in the crevicular fluid when the periodontitis stage has reached. These data suggest that the epithelial cells of the gingival tissue are involved in synthesis and secretion of TXB 2 , which occurred during the development of gingival inflammation.