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Hen egg‐white lysozyme inhibits biological activities of lipopolysaccharides from periodontopathic bacteria
Author(s) -
Ito H.O.,
Hirata M.,
Koga T.
Publication year - 1997
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1997.tb00537.x
Subject(s) - lysozyme , actinobacillus , microbiology and biotechnology , prevotella intermedia , bacteria , biology , limulus , secretion , in vitro , egg white , bacteroides , porphyromonas gingivalis , biochemistry , genetics , paleontology
Lysozyme has a bactericidal activity for some strains of Gram‐positive bacteria, by enzymatic cleavage of peptidoglycans that constitute the cell wall. Hen egg‐white lysozyme (HEL) was tested in vitro for effects on biological activities of lipopolysaccharides from periodontopathic Gram‐negative bacteria, Actinobacillus actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . HEL inhibited a wide range of activities of these lipopolysaccharides, including activation of Limulus amoebocyte lysate, stimulation of human leukocytes to secrete tumour necrosis factor‐alpha, polyclonal activation of mouse B cells, and promotion of osteoclastic differentiation in mouse bone marrow cultures. The anti‐endotoxic activity of HEL may be worthy of being intended for periodontal therapy.