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Analysis in gingival crevicular fluid of two oligopeptides derived from human hemoglobin β‐chain
Author(s) -
Mäkinen K.K.,
Sewón L.,
Mäkinen P.L.
Publication year - 1996
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1996.tb00462.x
Subject(s) - hemoglobin , dentistry , oligopeptide , medicine , chemistry , biochemistry , peptide
HPLC on a reversed phase column, amino acid sequencing and mass spectrometry were used to determine the structure of two human gingival crevicular exudate oligopeptides (Leu‐Thr‐Pro‐Glu‐Glu‐Lys‐Ser‐Ala‐Val‐Thr‐Ala‐Leu and Leu‐Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln‐Arg‐Phe) which were shown to have been derived from the β‐chain of hemoglobin. These sequences may simply represent two degradation products of the β‐chain. However, their preservation in an exudate characterized by active peptidolysis may also prompt the question about their possible more specific role.