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Acute‐phase proteins in gingival crevicular fluid during experimentally induced gingivitis
Author(s) -
Adonogianaki E.,
Moughal N. A.,
Mooney J.,
Stirrups D. R.,
Kinane D. F.
Publication year - 1994
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1994.tb01213.x
Subject(s) - gingivitis , lactoferrin , medicine , oral hygiene , acute phase protein , alpha (finance) , fibrinogen , gastroenterology , dentistry , inflammation , surgery , chemistry , biochemistry , construct validity , patient satisfaction
The dynamics of four acute‐phase proteins were investigated in gingival crevicular fluid (GCF) during the course of a 21 day experimental gingivitis study. These acute‐phase proteins were the protease inhibitors α2‐macroglobulin (α2‐M) and α1‐antitrypsin (α1‐AT) and the iron‐binding proteins transferrin (TF) and lactoferrin (LF). 6 healthy volunteers ceased all oral hygiene procedures for 3 weeks. GCF was sampled at seven day intervals from two sites per subject by paper strips for 30 s during the experimental gingivitis period and for two additional weeks after the reinstitution of oral hygiene. The mainly serum derived α2‐M, αl‐AT and TF exhibited very similar dynamics which reflects their common origin in GCF. Their levels increased significantly from baseline and remained high for at least one week after the reinstitution of oral hygiene measures (repeated measures MANOVA; α2‐M: p=0.015; α1‐AT: p=0.012; TF: p=0.02). This probably reflects increased vascular permeability in the gingivae and, to a lesser degree, local production by gingival inflammatory cells. In contrast to the serum derived acute‐phase proteins, the neutrophil derived LF rose significantly from baseline (repeated measures MANOVA; p=0.001) but dropped rapidly after the reinstitution of oral hygiene measures. This could be because dental plaque was removed and thus neutrophil chemotactic agents in the crevice were decreased.