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Depressed helper‐to‐suppressor T‐cell ratios in early‐onset forms of periodontal disease
Author(s) -
Kinane D. F.,
Johnston F. A.,
Evans C. W.
Publication year - 1989
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1989.tb02000.x
Subject(s) - periodontal disease , cd8 , medicine , gastroenterology , flow cytometry , disease , significant difference , suppressor , immunology , immune system , cancer
Helper (CD4 + )‐to‐suppressor (CD8 + ) T‐cell ratios were determined by flow cytometry for 12 patients with early‐onset forms of periodontal disease and their appropriate controls. When considered as a group, patients with early‐onset periodontal disease showed a markedly depressed CD4 + /CD8 + ratio relative to controls (means 0·92 and 1·50 respectively). This difference was significant at the 0·0015% level as determined by the Mann‐Whitney test. Separate analysis of patients with either the juvenile or rapidly progressive types of early‐onset periodontal disease showed both to have reduced CD4 + /CD8 + ratios (means 0·91 and 0·92) relative to their controls (means 1·57 and 1·45) which were both statistically significant (p<0·05).