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Distribution of 3 H‐fucose in the transseptal ligament of the mouse
Author(s) -
Johnson Roger B.
Publication year - 1988
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1988.tb01614.x
Subject(s) - periodontal fiber , molar , ligament , medicine , anatomy , fucose , biology , chemistry , zoology , endocrinology , glycoprotein , biochemistry , dentistry , paleontology
The present study demonstrated 3 H‐fucose distribution in three regions of the transseptal ligament; the middle, mesial (adjacent to the first molar tooth) and distal (adjacent to the second molar tooth) thirds; of 6‐week‐ and 6‐month‐old Swiss mice. Incorporation of the isotope was rapid and maximal peaks occurred at 3 hours in most regions of 6‐month and at 12 h in most regions of 6‐wk animals: highest grain counts were over the middle third of the ligament of 6‐wk animals (p<0.001). During incorporation, mean grain counts were significantly different as a function of age (p<0.001), region (p<0.01) and time (p<0.001) and there was a significant interaction between region and time (p<0.005). Grain removal occurred at a slower rate: there were significant differences in mean grain counts as a function of age (p<0.001), region (p<0.001) and time (p<0.001) and a significant interaction between time and region (p<0.001) and between time, region and age (p<0.001). The highest rate of grain removal was in the middle third of the ligament of 6‐wk animals. Half‐life of labeled glycoproteins was shortest in the ligament of 6‐wk animals. The study suggested regional differences in metabolism of fucose‐containing glycoproteins of the transseptal ligament: highest turnover rates in the 1) middle third, and 2) young animals.