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The action of sodium fluoride on suspected periodontopathogens
Author(s) -
Yotis W. W.
Publication year - 1988
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1988.tb01428.x
Subject(s) - treponema denticola , fusobacterium nucleatum , microbiology and biotechnology , actinomyces , porphyromonas gingivalis , fusobacterium , chemistry , bacteria , bacteroides , alkaline phosphatase , enzyme , dental plaque , acid phosphatase , bacteroidaceae , phosphatase , biochemistry , biology , genetics
Certain oal bacteria have been implicated in the initiation of chronic gingivitis and the progression of periodontitis. The present study was conducted to assess the influence of sodium fluoride on the in vitro growth and on various enzymes of Treponema denticola, Actinomyces actinomycetemcomitans, Fusobacterium nucleatum and 3 Bacteroides species. Complete inhibition of growth for 5 strains of T. denticola , 3 strains of A. actinomycetemcomitans , 3 black‐pigmented strains of Bacteroides and 3 strains of F. nuclatum was observed with 40, 80, 160, and 320 μg/ml of F‐ respectively. The API system, a convenient and rapid method designed to detect 19 enzymes, was employed primarily to determine the relative sensitivity of demonstrable enzymes to F ‐ for the assay microorganisms. F ‐ concentrations of 10–60 μg/ml inhibited the acid phosphatase of T. denticola or the acid and alkaline phosphatase of A. actinomycetemcomitans . However, F ‐ at a concentration of 10–60 μg/ml did not influence any of the detectable enzymes of the other assay bacteria. Periplasmic phosphatases hydrolyze impermeable phosphate esters to compounds that could then be transported and utilized by the cells.